Anti-Inflammatory TLRs in the Infected Proinflammatory TLRs While Upregulating Vasoactive Intestinal Peptide Downregulates
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High-mobility group box 1: a novel target for treatment of Pseudomonas aeruginosa keratitis.
High-mobility group box 1 (HMGB1), a prototypic alarmin, mediates the systemic inflammatory response syndrome. Treatment with vasoactive intestinal peptide, an anti-inflammatory neuropeptide, downregulates proinflammatory cytokines and promotes healing in a susceptible (cornea perforates) model of Pseudomonas aeruginosa keratitis, and also significantly downregulates HMGB1 expression. Therefore...
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تاریخ انتشار 2012